On January 19, 2021
Finally, the author reviewed mechanism of action and safety data published to date. A U.S. based company Hyatt Life Sciences discovered that by fortifying the Arum extract with other additives such as isovanillin, harmala, and turmeric, it’s cancer-fighting effects are enhanced.2 Hyatt’s unique blend, dubbed Afaya Plus, is available as a dietary supplement. Will grow in a dry spot but performs better if watered during dry periods. Arum palaestinum Boiss. Cells from the prostate cancer cell line 22Rv1, a recognized model of androgen-independent cancer,42 were placed in a 3D cell culture system forming spheroids. Complementary and alternative medicine use among cancer patients in Palestine with special reference to safety-related concerns. Mit diesem Duft, so stand zu vermuten, lockt die Schwarze Calla ihre Bestäuber an, nämlich Fruchtfliegen. Despatched from mid-February. Arum palaestinum makes a glamorous choice for the garden. Reis M, Ferreira RJ, Serly J, et al. The data to date i… KEYWORDS: Arum Palaestinum, anticancer, herbal medicine, crude extract. My husband wants to know if it's okay to take a supplement called "Afaya Plus", which is mainly made up of an herb called Arum Palaestinum Powder, at the same time he will be getting immunotherapy treatments by IV to fight off cancer cells that have spread to his lungs. Arum palaestinum, a perennial plant that produces a deep purple lily flower, has a long history of use as a medicinal plant in the Middle East, including as a cancer treatment. Due to quarantine, cannot post to Overseas. Figure 4. It contains a number of phytochemicals known to exert anticarcinogenic effects, and when its water extract is fortified with several constituents endemic to the plant, namely isovanillin, linolenic acid, and β-sitosterol, a synergistic anticarcinogenic effect is seen against prostate cancer cells. Afaya Plus should be taken with a fat-containing meal and is typically dosed at two capsules, 1-3 times a day. Ma L, Peng H, Li K, et al. The lipophilic fractions of Arum palaestinum, Malva sylvestris, Plantago major, Centaurea iberica, Cichorium endivia, Bituminaria bituminosa, Sisymbrium irio leaves were sequentially separated with a nonpolar solvent hexane, while the hydrophilic fractions of the studied plants were separated with polar solvents ethanol and water. Potential risks associated with traditional herbal medicine use in cancer care: A study of Middle Eastern oncology health care professionals. The purple spathe and reddish spadix of Arum palaestinum. is a flowering perennial species within the family Araceae, also known by its common name as Solomon’s lily,1 and often referred to in literature as black calla lily.2 Arum palaestinum’s membership in the larger botanical family of Araceae is significant from an ethnobotanical perspective, as this family is coming to be viewed as a particularly rich source of medicinal botanicals.3, Arum palaestinum is included in the genus Arum L, along with Arum italicam Mill. If Arum Palaestinum is the engine that drives the Afaya Plus ® formula, then Peganum Harmala is the high-octane gasoline that helps achieve peak performance. Caffeine and caffeic acid inhibit growth and modify estrogen receptor and insulin-like growth factor I receptor levels in human breast cancer. arum as a wild species such as Arum macula tum L. or A. italicu m L., while Littre ´ [ 92 – 93 ] con- sidered it to be Arum Colocasia (an old botanical name for taro). Afifi FU, Khalil E, Abdalla S. Effect of isoorientin isolated from Arum palaestinum on uterine smooth muscle of rats and guinea pigs. I believe the name of the IV drug is Keytruda. Molecular mechanisms and therapeutic effects of (−)-epicatechin and other polyphenols in cancer, inflammation, diabetes, and neurodegeneration. It is native to Western Asia, Northern Africa, Europe and widely distributed in Mediterranean region . Arum palaestinum NC State University and N.C. A&T State University work in tandem, along with federal, state and local governments, to form a strategic partnership called N.C. The inner spathe is a sensational velvet black. In traditional medicine among Arabs in Palestine, Arum palaestinum extracts have been used for cancer, intestinal worms, infections in open wounds, urinary tract obstructions, and kidney stones, and are thought to strengthen bones. Directions: As a dietary supplement, take 1-2 capsules orally twice per day (approximately 10-12 hours apart) with a meal that contains some form of healthy fat such as milk, yogurt, avocado, etc. Vishwakarma V, New J, Kumar D, et al. Table 3. Arum palaestinum is a plant commonly found in the Middle East that is ingested as an herbal remedy to fight cancer. Frequently called arum lilies, they are not closely related to the true lilies Lilium. and Farid et al., . Shahali A, Ghanadian M, Jafari SM, et al. In this interview, Benton Bramwell, ND, discusses the unique Mediterranean herb Arum palaestinum. Mitochondrial and caspase pathways are involved in the induction of apoptosis by nardosinen in MCF-7 breast cancer cell line. If Arum Palaestinum is the engine that drives the Afaya Plus ® formula, then Peganum Harmala is the high-octane gasoline that helps achieve peak performance. According to a 2008 ethnobotanical study of edible plants within 5 rural districts of the Palestinian Authority, where preservation of the traditional knowledge of wild edible plants would be expected to be best maintained, Arum palaestinum was identified as one of the species rated highest for its cultural importance, a reflection of the diversity of ways in which an item is used as a food (eg, a vegetable, an herbal tea), and was cited by over half of those surveyed as a wild plant used for a food purpose.8 Consistent with a combined food-medicine use, Arum palaestinum is described in this survey as a food that is prepared by the leaves boiled in water, fried in olive oil, garnished with lemon, and consumed because of the belief that the plant helps prevent colon cancer. The rate of tumor volume increase was 73 mm, Tumor growth delay was measured when control tumors reached a volume of 500 mm. Arum palaestinum Boiss., also called Black Calla, is a perennial herbaceous plant from subfamily Aroideae (family: Araceae). Yuan L, Wang J, Xiao H, et al. Arum TSN 42543. Here's a new video of one of the beautiful plants in my garden. Narisawa T, Fukaura Y, Yazawa K, et al. Flavonoid C-glucosides derived from flax straw extracts reduce human breast cancer cell growth in vitro and induce apoptosis. Ye T, Su J, Huang C, et al. Anti-cancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancer. estine, Arum Palaestinum has been employed to treat conditions that range from cancer to infections to intes - tinal worms. Luteolin exerts an anticancer effect on NCI-H460 human non-small cell lung cancer cells through the induction of Sirt1-mediated apoptosis. Knight attributes his survival in large part to Zaid and his creation Afaya, a mixture of black calla lily (arum Palaestinum) and other extracts. Wattenberg LW. Through rather extensive analysis of Arum palaestinum via liquid chromatography tandem-mass spectrometry (LC-MS), combined with previously published literature, Abu-Reidah10 reports the presence of 180 phytochemicals (with tentative identification), including 53 flavonoids, 33 phenolic acids, 10 terpenoids, 7 iridoids, and 6 amino acids, obtained from a hydro-methanolic extract. Comparison of Organ Weight in Mice Treated with GZ17 vs Vehicle. The spathes have a soft, olive-green exterior, this calm colouring encases a dramatic interior. Coach Bill Snyder Thank You, Coach Bill Snyder, and Kansas State University, for Your Continued Support of Our Goal Here at Hyatt Life Sciences: To Help As Many People As Possible! Wu XX, Kakehi Y. Enhancement of lexatumumab-induced apoptosis in human solid cancer cells by cisplatin in caspase-dependent manner. In addition, a cautious approach would still be advised as far as spacing it out from some types of chemotherapy agents where interactions cannot be ruled out. Here we tested the antitumor efficacy of synthetic formulations of Arum palaestinum extract (GZ17-S, -05.00 and -06.02) in preclinical models of HNSCC. In summary, the results suggest that Arum palaestinum has shown anti-tumor activity which were strongly correlated with their bioactive contents. On this episode we learn more about the fascinating Mediterranean botanical Arum Palaestinum. The preservation and conservation of A. palaestinum were carried out by Shibli et al. The size of tumors and the rate of tumor growth were both statistically significantly greater in the mice treated with vehicle vs the mice treated with GZ17. Alpha-linolenic acid stabilizes HIF-1 α and downregulates FASN to promote mitochondrial apoptosis for mammary gland chemoprevention. As shown in Figure 4, GZ17 shows significant reduction of prostate cancer cell number at a concentration of about 0.2 mg/mL, compared to control vehicle. The plant is widely used in Traditional Arabic Palestinian Herbal Medicine (TAPHM) in the treatment of several human diseases mainly cancer. Diese werden in der Blüte … Cooperative Extension, which staffs local offices in all 100 counties and with the Eastern Band of Cherokee Indians. The arrangement of its leaf blades speaks to a commonly used, aptly descriptive name in Arabic that translates to “elephant ear” (Figure 2),5 while its seeds are identifiable by their vibrant red color (Figure 3). Dr. Benton Bramwell explains to listeners exactly how this herb can help improve health on a deep cellular level. On this episode we learn more about the fascinating Mediterranean botanical Arum Palaestinum. Figure reproduced with permission from Genzada Pharmaceuticals.14. Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model. The present study sought to evaluate the exhaustive extract yields percentages for Solomon's Lily (Arum palaestinum Boiss.) is a species of herbaceous plant belonging to the Araceae family [1,2]. Through extensive research and study, we witnessed the power of unique ingredients such as Arum Palaestinum and Peganum Harmala, two key components in our Afaya Powered products. Antileukemic activity of phenylalanine methyl ester (PME): a lysosomotropic peptide methyl ester. Due to quarantine, cannot post to Overseas. Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells. These wonderful plants have been grown and used for over a millennia in Central and Southeast Asia and the Middle East. Most arums are easy to grow in a semi-shaded area forming clumps if left undisturbed. Evaluation of analgesic activity of the methanol extract from the leaves of Arum palaestinum in mice and rats. leaves considered one of the most edible wild plant in Palestine also one of the medicinal plant utilized for treatment various diseases specially cancer. As for safety, there are no significant concerns given its historical use in the Middle East and the early clinical evidence. Recent work demonstrates anticarcinogenic action both in vitro and in vivo, and that work is coupled with a proof-of-principle mechanism of action data showing induction of the pro-apoptotic protein, caspase-6. These striking flowers hail from the rugged reaches of the Middle East Recent work demonstrates anticarcinogenic action both in vitro and in vivo, and that work is coupled with a proof-of-principle mechanism of action data showing induction of the pro-apoptotic protein, caspase-6. Ali-Shtayeh MS, Jamous RM, Al-Shafie' JH, et al. Arum palaestinum Boiss. Hope you like watching it. Ali-Shtayeh MS, Jamous RM, Salameh NM, et al. This strongly suggests that the description by Dios… GZ17 slowed tumor growth when compared to the vehicle group with only a 9.6% increase in tumor size. However, excess free radicals created by the immune system and environmental toxins severely damage cells. Samples were submitted to the Missouri Botanical Garden, St. Louis, MO for verification (voucher number, Croat 95,466(MO). Tumor growth in vehicle-treated mice and mice treated with CZ17. Prostate cancer cells of line PC3-MM2 were injected subcutaneously into male nude mice and the mice were subsequently followed over a 3-week period. Bramwell B. Arum palaestinum as a food-medicine: a diverse history and a bright future. Qnais E, Bseiso Y, Wedyan M, et al. Jaradat N, Abualhasan M. Comparison of phytoconstituents, total phenol contents and free radical scavenging capacities between four Arum species from Jerusalem and Bethlehem. Arum palaestinum TSN 811045. The floral odour of A. palaestinum smells like fermenting fruit or wine and attracts Drosophila sp. Arum creticum produces a sweet, flower-like odour and is pollinated by bees and bugs. The blooms have a yeasty fragrance and are pollinated by insects. Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds. Nearly 40 % of the cancer patients ingesting the plant revealed that they anticipated a cure due to the plant. Shay J, Elbaz HA, Lee I, Zielske SP. Early results show that the Afaya Plus blend of herbal extracts has exhibited strong anticancer effects both in vivo and in vitro. The author also reviewed the recently published in vitro and in vivo literature related to the anticarcinogenic activity of an extract of Arum palaestinum fortified with isovanillin, linolenic acid, and β-sitosterol, constituents that are endemic to a crude water extract of Arum palaestinum. They are native to Europe and the Mediterranean region and although some of them omit an unpleasant smell, to attract insects for pollination, they are well worth growing. As shown below in Table 3 and Figure 8, there was no difference seen in the organ weight or morphology across the 2 groups, and the weight of the treatment mice was not significantly less than the control mice. © 2021 Riordan Clinic, All Rights Reserved. The results showed that Arum palaestinum extracts were found to be most effective against leukemia (k562) and colon cancer (HCT-116), and ethyl acetate extracts showed the best effect. Previous studies have showed that GZ17-6.02 significantly inhibited PDAC tumor growth in an orthotopic xenograft mouse model for PDAC. By day 6 and for all subsequent measurements there was a statistically significant increase in the tumor volume of the vehicle-treated mice. Yang G, Wang Z, Wang W, et al. 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